COENZYME Q10: ANTIOXIDANT AS USEFUL
TREATMENT ADJUNCT:
A REVIEW: Part III
Co-enzyme 10 and
periodontal disease - Concluding part of this review.
by- Dr.Vinayak
Joshi
Periodontal Disease:
Periodontal disease is primarily an inflammatory disease, which is initiated
by the gram negative bacteria present in the plaque, which the in
combination with certain host immune response leads to further progression.
The presence of malnutrition or systemic disease acts as an adjunct to the
primary factor i.e. plaque in the progression of the periodontal disease.
It is
well documented by various studies that deficiency of folic acid and vitamin
A, C, and B complex along with poor oral hygiene results in increased
periodontal inflammation.
The
activity of bacteria agglutinating glycoprotein in saliva is decreased in
malnutrition, and this may promote enhanced formation of dental plaque and
an overgrowth of potential perio-pathogens in malnutrition may contribute to
periodontal disease occurrence. The malnutrition also affects the host
response by suppressing production and cellular activation of cytokines,
inverts the helper-suppressor T cell ratio, thereby affecting the natural
defense mechanism. The CoQ10 are specifically utilized in energy production
in cells. It has been shown that human gingival tissue contain coQ10 enzyme.
The debate on the influence of CoQ10 in inflamed periodontal disease has
been a long one. In 1960’s Tsunemitsu et al, and Matsumura et al studied
effects of CoQ10 administration on hypercitricemia, showed that prolonged
administration of CoQ10 alleviated the histopathologic alterations found in
citrated rats. Lttarru et al 1971, found that gingival biopsies from
patients having diseased periodontal tissues showed a deficiency of
CoenzymeQ10 in control to those of the normal periodontal tissue which
showed no deficiency. Nakamura et al in 1973 found that about 60% of the
diseased gingival tissues showed deficiency of CoQ10 as compared to 20% of
the control tissues. He concluded from the result that there was a
deficiency of CoQ10 in the diseased gingival.
However there have been studies conducted in animals and humans which showed
the contrary results. Several studies have shown varying results like,
Periodontal disease dose not affect CoQ10 levels, no affect of
administration of CoQ10 on the specific activity or the mitochondrial
enzymes in gingival, minimal or no affect of CoQ10 administration on plaque
or gingival indices, pocket depth or periodontal disease.
The
effects of CoQ10 on the immune system of patients with periodontal disease
were also studied. The T4/T8 ratio increased after 2 months of CoQ10
administration, while IgG levels increased significantly after 6months
according to the study by Hanioka et al 1993. The affect of topical
application of CoQ10 was studied by McRee et al 1993, and Hanioka et al
1994.The results of former suggested a very limited use effect after CoQ10
administration, while the results of the latter were inconclusive.
Further Research:
CoQ10
is known to improve the immune system by increasing the T4/T8 ratio and IgG
levels. IgG is one of the important defense mechanism of gingival tissue as
this immunoglobulin is found in high concentration in this tissue. CoQ10 is
also known to improve the phagocytic activity of macrophages. CoQ10 can be
combined with other host modulating agents like Sub antimicrobial Dosage of
Doxycycline (e.g. Periostat), or Non steroidal anti-inflammatory agents (flubriprofen).
The SDD is known to decrease the metalloproteinase enzymes in periodontal
disease animal and human models. The CoQ10 which acts as a bioenergetic in
the cellular function can act in combination with these drugs to give a
combined or a synergistic affect. CoQ 10 could also be combined with other
treatment modalities.
Conclusion:
The
importance of CoQ10 as a bioenergetic in the cellular functions is
established by previous research. The multifactor etiology in the
periodontal disease makes the treatment a challenge. CoQ10 can be used an
additional armor in the treatment protocol of this complex disease. The use
of CoQ10 alone or in combination with other agents and treatment procedures
is potential area of further research.
Refrences:
-
Battino M., Bullon P., and H. Newman: Oxidative Injury and infkammatory
periodontal diseases: the challenge of antioxidants to free radicals and
reactive oxygen species. Crit rev Oral Biol Med ,1999 ;10 (4): 458-476
-
Gaby A.R. The Role Of Coenzyme Q10 In Clinical Medicine Part I.
Alternative Medicine Review 1996 (May); 1 (1): 11–17
-
Gaby A.R.
The Role of Coenzyme Q10 in Clinical Medicine: Part II
Cardiovascular Disease, Hypertension, Diabetes Mellitus and InfertilityAlternative
Medicine Review 1996 (Sep); 1 (3): 168–175
-
Hanioka T,
Tanaka M,
Ojima M,
Shizukuishi S,
Folkers K.
,Effect of topical application of coenzyme Q10 on adult periodontitis. Mol
Aspects Med. 1994;15 Suppl:s241-8.
-
Littarru GP, Nakamura R, et al.
Deficiency of coenzyme Q10 in gingival tissue from patients with
periodontal disease. Proc Natl Acad Sci 1971;68:2332-2335.
-
Nakamura R, Littaru GP, et al.
Deficiency of coenzyme Q in gingiva of patients with periodontal disease.
Int J Vitam Nutr Res 1973;43:84-92.
-
SchachterM.B.,CoenzymeQ10.
http://www.mbschachter.com/coenzyme_q10.htm
-
http://www.umm.edu/altmed/ConsSupplements/CoenzymeQ10cs.html
-
http://www.doctormurray.com/articles/CoenzymeQ10.htm
-
http://www.thorne.com/pdf/journal/3-1/co_q10_monograph.pdf
-
http://www.mayoclinic.com/health/coenzyme-q10/NS_patient-coenzymeq1
Dr Vinayak M. Joshi M.D.S ( perio)
RASHA RECOMMENDS
.............
EVENTS:-
INDIA INTERNATIONAL DENTAL CONGRESS

The best of Indian Dentists will be meeting
the World's best Dentists at the forthcoming India International Dental
Congress [IIDC] to be held at Nehru Centre, Mumbai, India from February 22nd
- 25th 2007. For the first time in India an offer to earn internationally
recognized credits of 18 class hours from New York University - American
Dental Association [ADA].
As these words are read, only a few months
remain before the commencement of this international event. Such a
convention takes years of planning and the collaboration of a multitude of
professional organizations and associations, the generous participation of
the international dental industry without whom the realization of a meeting
of this magnitude would be difficult if not impossible.
Never before seen in India, be sure not to
miss the pre symposiums and the main symposium on the latest developments in
dentistry that will take place daily throughout the four convention days.
With the participation of eleven international experts, who will be here to
share and discuss the latest technologies and recent materials. The dental
exhibition will be the largest ever seen in India with outstanding pavilions
showing the latest products on the dental market.
Allow me to remind you to pre-register at
the earliest, with the risk of disappointment due to lack of space. Many
pre-conference courses and workshops are sold-out, however, you must
absolutely reserve your place in advance with the number of available seats
being limited.
You are also invited to attend the various
festivities that will take place during the congress, which, in my opinion,
will present an excellent opportunity to meet, exchange and socialize with
colleagues from around the world.
I count on your participation. I look
forward to your deep dedication towards continuing dental education, an
essential commodity in the pursuit of a valuable dental practice.
For further detailed information please
visit
www.iidc.in
<http://www.iidc.in/> or email
cde@smilecareindia.com
See you at IIDC!
Dr. Ratnadeep Patil
Information
Schedule Update:
21st February 2007 - Meet the Mentor 4.00pm
- 6.00pm
22nd February 2007 - Pre-Congress Courses
9.00am - 4.00pm
23rd February 2007 - Pre-Congress Courses
8.30am - 3.00pm
- Main Congress 3.30pm - 7.00pm
24th February 2007 - Main Congress 8.30am -
6.00pm
25th February 2007 - Main Congress 8.30am -
5.00pm
Pre-Congress Courses:
Pre-congress 1 Code: 2201
Speaker: Dr. Gerard Chiche
Time:09:00am - 4:00pm Date: 22nd February
2007
Recipes for predictable anterior esthetics.
This course will discuss the key areas for
efficient esthetic diagnosis and smile design. These key points will be
formulated into a simple and systematic step-by-step approach to resolve
esthetic problems and achieve predictable esthetic results and improved
laboratory support.
Topics to be covered include:
Key factors for treatment planning and
establishing prognosis for esthetic success.
Shade taking in three simple steps and
identifying shading effects for the young tooth and plan special effects or
imperfections to achieve life-like restorations
Discuss preparation design, variations
and indications for porcelain veneers.
Demonstrate a predictable porcelain
veneer bonding technique.
Discuss the rationale for cement
selection for porcelain veneers.
Outline of prosthetic and adhesive
techniques in terms of armamentarium and products.
Pre-congress 2 Code: 2202
Speaker: Dr. Nitzan Bichachao
Time:09:00am - 4:00pm Date: 22nd February
2007
Towards the esthetic dream through a
holistic concept.
This course will incorporate innovative
techniques and new restorative concepts that are critical for arriving at
long lasting, natural looking natural dentition and implant restorations.
The first part will deal with natural dentition contemporary treatment
modalities, whereas the second part will concentrate on dental implants
therapy. Analysis of new treatment modalities and treatment plans and
clinical procedures - from the diagnostic previews through provisionals,
soft tissue development concepts and techniques - towards the optimal
definitive tooth or implant-supported restoration. Discussion on the
importance of the team approach between patient, lab technician and the
clinicians from different specialties that is essential for the esthetic
success of predictable, long lasting restorations.
Pre-congress 3 Code: 2203
Speaker: Dr. Michael Sonick
Time:09:00am - 4:00pm Date: 22nd February
2007
Periodontal Surgical Designs and
Techniques.
A variety of surgical techniques and their
rationale will be demonstrated for pocket elimination as well as
regenerative procedures including bone grafting and guided tissue
regeneration. Suturing styles, techniques and indications will be discussed
in detail including simple interrupted, continuous sling, horizontal
mattress, internal vertical mattress and external vertical mattress. An
appreciation for the predictable regeneration of soft tissue for health and
esthetics with knowledge essential for the successful incorporation of these
techniques into practice will be gained.
Topics to be covered include:
When is periodontal surgery indicated ?
When to use the various surgical
techniques ? - An attempt will be made to make sense out of the multiplicity
of flap procedures and designs, including indications for sulcular vs.
inverse bevel incisions, full thickness vs. split thickness flaps, and
apically positioned vs. repositioned flaps.
Different periodontal surgical procedure
and suturing techniques and when to apply them
A papillary retention flap technique for
anterior maxilla will be demonstrated. This flap enables one to provide
anterior pocket elimination without disfiguration. Indications for muco-gingival
surgery will be discussed. The free gingival graft and the sub-epithelial
connective tissue graft will be demonstrated in detail.
Altering the dental gingival junction and
ridge augmentation and root coverage Procedures for ideal esthetic
rehabilitation
Pre-congress 4 Code: 2204
Speaker: Dr. Giuseppe Cantatore
Time:09:00am - 4:00pm Date: 22nd February
2007
Use of the New Rotary Nickel-Titanium
Instruments [A Hands-on Session]
During the last few years a revolution has
occurred in root canal preparation, thanks to the introduction of the new
rotary nickel-titanium instruments. It is now possible to treat difficult
cases with long and curved canals with great results, dramatically reducing
working time. Nevertheless Ni-Ti instruments show several drawbacks and
require proper handling and operating sequence to avoid complications.
The topics covered will be:
Features and clinical use - blade design,
tip design, alloy, the new endodontic motor with autoreverse and torque
control
Advised Instrumentation sequence (with
video demonstration)
Hybrid technique: combined use of
different kinds of rotary instruments: when and why.
Basic principles to avoid the breakage of
the Ni-Ti instruments.
Pre-congress 5 Code: 2205
Speaker: Dr. Dario Adolfi
Time:09:00am - 4:00pm Date: 22nd February
2007
Procera Technology and Nobel RondoTM [ A
Hands-on Session]
Pre-congress 6 Code: 2301
Speaker: Dr. Dennis Tarnow
Time:08:00am - 3:00pm Date: 23rd
February 2007
Controversies and Innovations in Implant
Dentistry.
Implant dentistry is continuously evolving
into a more predictable form of therapy. This full day program will answer
the FAQs regarding many controversial issues as they relate to early
loading, predictability, membrane placement, membrane type, grafting,
primary closure, immediate placement, immediate temporization, to mention a
few. The program will address and interweave the innovations in implant
dentistry and how they can enhance your clinical outcomes for greater
patient satisfaction.
Pre-congress 7 Code: 2302
Speaker: Dr. Daniel Edelhoff
Time:08:30am - 3:00pm Date: 23rd
February 2007
Esthetics with All Ceramic Restorations.
This course will introduce the participants
to selection of cases for all ceramic restorations, indications and
contraindications, Tooth preparation design and their rationale. All ceramic
restorations need acute shade selection, effective lab Communication and a
thorough understanding of color concepts for optimum results. Selection of
right type of luting cement is another key area that will be discussed in
depth. Cementation procedures and finishing and maintenance of the
restoration will also be dealt with methodically.
Pre-congress 8 Code: 2303
Speaker: Dr. Mark Pittel
Time:08:30am - 3:00pm Date: 23rd
February 2007
Creating Dazzling Smiles with Direct
Composite Resins
Restorative dentistry is not just about
form and function. It is also about integrating dental materials with the
laws of nature to create something of extraordinary beauty. The art and
science of adhesion dentistry and composite resins have turned the placement
of esthetic resin restorations into an art form that allows patients an
excellent alternative to ceramics without significant compromise.
3-dimensional multi-layered direct composite restorations can now closely
rival the functionality and beauty of natural tooth structure. They offer
the benefits of full artistic control for the dentist without a lab bill,
reduced tooth preparation for the patient and the convenience of a single
appointment. In this course, state of the art techniques for the placement
of anterior and posterior direct composite restorations will be covered in
detail. The program will also provide an update on the latest concepts in
adhesive technology through the "all in one" 7th generation, self etching
adhesive materials. Harness your creative skills and learn how to use simple
techniques to dazzle your patients utilizing the powers engineered into
today's restorative materials.
The topics covered will be:
A comparative discussion of the benefits,
features and limitations of microhybrids, microfills and the newer
nanofilled composites
A common sense protocol for restoring
small, medium and large size posterior cavities rapidly and esthetically
with direct resin restorations
Strategies for shade selection
Clinical cases; durable and easy incisal
edge repairs, "diamond orthodontics", the large class IV, diastema closure,
tunnel preps, class III repairs
Complete step by step protocol for
posterior composite placement
Working with diagnostic waxups and
clinical templates
Layered composite concepts, techniques
and strategies
An update on adhesion dentistry with an
emphasis on predictable, durable and trouble free bonding with detailed
information about the newest 7th generation, "all-in-one" self etching
adhesives
What are the limitations and
compatibility issues with self etch adhesives? Much, much, more
Social Events
Faculty Dinner- 22nd February 2007
A special dinner will be hosted in honor
and appreciation of the visiting international faculty and will provide an
opportunity for close interaction with them. This dinner is by invitation
only.
NYU Alumnus Dinner Meet - Friday 23rd
February 2007
Everyone who has been associated with the
New York University College of Dentistry International Postgraduate
Certificate Program in the past, either as faculty or participant, is
cordially invited to be a part of this occasion. This will be an opportunity
for all to meet, reminisce, share with one another their experiences
post-NYU, and generally enjoy an evening of fun and nostalgia. Prior
reservation is mandatory for attending. There will be no registration fee.
Gala Dinner - Saturday 24th February 2007
Theme: Night Out At Las Vegas - Experience
a magical journey of sight, sound and taste. Enjoy an evening of dinner and
dance and explore the great opportunity to party with friends and fellow
colleagues.
Registration Details
Plan A [RS. 16500]
Choice of any 2 Pre-Congress Courses
Registration for the Main Congress (Inclusive of Lunches)
18 credit hours for CDE
Trade Show
Trade Talk
Focused Workshop
Gala Dinner
Plan B [RS.13000]
Choice of any 1 Pre-Congress Course
Registration for the Main Congress (Inclusive of Lunches)
18 credit hours for CDE
Trade Show
Trade Talk
Focused Workshop
Gala Dinner
Plan C [RS. 11000]
Choice of any 2 Pre-Congress Courses
(Inclusive of Lunches)
Lucky Dip
Plan D [RS. 7000]
Choice of any 1 Pre-Congress Course
(Inclusive of Lunch) Lucky Dip
Plan E [RS. 7500]
Registration for the Main Congress
(Inclusive of Lunches)
18 credit hours for CDE
Trade Show
Trade Talk
Focused Workshop Gala Dinner
Lucky Dip
Plan F [RS. 11500]
(Technician's Plan) Pre-Congress Course
Code: 2205
(Inclusive of Lunch)
Trade Show
Please Note:
Please Note:
Registrations will also be accepted at the
IDA Meet at the Nobel Bio-Care Stall in Pune on 6th &7th January 2007.
* Forms that can be download from the
website www.iidc.in <http://www.iidc.in>
Download Registration Form for Congress/PreCongress:
Download Registration Form for Poster and
Paper Presentation:
Download Registration Form for Meet the
Mentor Program:
Download Registration Form for NYU Alumni
Meet
Lasers In
Dentistry - I
By - Dr.Maziar Mir
DDS, Msc.Phd
In 1997, internet was considered as a very modern service in my dental
school and we were not able to estimate to have such an advance information
source in our rooms 24 hours of day! Technology provides faster than what we
could imagine !!! At the same year (1997) the Food and drug Administration
(FDA) in US approved the Erbium:YAG lasers for cavity preparation and I
received that news by YAHOO ALERT, so decided to learn it earlier to prevent
the LACK OF KNOWLEDGE, as what happened about INTERNET in our school. Till
2002 mostly did just laboratory researches with some BIG Nd:YAg lasers and
working with lasers in my daily dental treatments was as a dream, but by
entering to the RWTH Hospital, understood that it is more than 10 years,
every body was using the LASERS for different applications daily and
routine! as we use K-file!
Now, on 2007 the year of CHANCE and LOCK, I thank god that I do 70% of my
treatments without giving the stress of INJECTION to myself, my staff and my
patients! Just now, there was a call from a patient, who came to me with an
ABSCESS at the apex of tooth 21 (Upper left central). I made the cavity with
Er:YAG laser (300 mJ, 15-20 Hz, 200 microseconds pulses) and sterilized the
CANAL with Nd:YAG, after flaring that with normal finger files till ISO 45!
The Nd:YAg setting was 1.5 Watt and 15 Hertz (Hz). The next step that I did
is not possible to be done without laser! I entered the Nd:YAG fiber to the
LESION at the soft tissue directly on the APEX area and patient although did
not receive any anesthesia but did not feel at all when the full procedures
were done and wondered at home how the ABSCESS is HIDED!!!
Fig-1 Patient at first visit
Fig-2 Er:YAG selective caries removal
Fig-3 Decontamination of root canal with Nd:YAG
I
wish, in all around the world, scientific dentists start to learn more about
LASERS and do not look only at having the most benefit with the CHEAPEST
POSSIBLE INSTRUMENTS. Our job is a HOLY one and our patients have the right
to use the COMFORT of today's modern technology assisted treatments.