A dinner speaker was in such a
hurry to get to the hotel that when he arrived and sat down at the head
table, he suddenly realized that he had forgotten to get his false teeth.
Turning to the man next to him he said, "I forgot my teeth." The man said,
"No problem." With that he reached into his pocket and pulled out a pair of
"Try these," he said. The speaker
tried them. "Too loose," he said. The man then said, "I have another
pair...try these." The speaker tried them and responded, "Too tight." The
man was not taken back at all. He then said, "I have one more pair...try
them." The speaker said, "They fit perfectly." With that he ate his meal and
gave his address.
After the dinner meeting was over,
the speaker went over to thank the man who had helped him. "I want to thank
you for coming to my aid. Where is your office? I've been looking for a good
dentist." The man replied, "I'm not a dentist. I'm the local undertaker."
C-reactive proteinó Part II
by- Dr.Vinayak Joshi
C-reactive protein (CRP) values can be
increased for multiple reasons. A major increase in CRP values is seen with
infections (e.g. Bacterial, viral, fungal, or
parastic infection), hypersensitive complications of infections (e.g.
Rheumatic fever), acquired and inherited inflammatory diseases (e.g.
Rheumatoid arthritis, Ankylosing spondylitis), tissue necrosis (e.g.
Myocardial infection, Tumor embolization), trauma ( e.g. burns, surgery),
neoplasia ( e.g.carcinoma, sarcoma), and also moderate increase in systemic
lupus erthematousus, scleroderma, and graft vs.- host disease.
However the relation between CRP values and
cardiovascular diseases (CVD) is the major area of focus, reason being the
high prevalence of this disease in the developed and developing countries
If you consider the number of studies coming
out of the literature trying to link the high CRP levels and the occurrence
of cardiovascular events, the relations seems to grow stronger.
Possible hypothesis for occurrence of CVD:
CRP is regulated by interleukin -6 (IL6),
interleukin 1, tumor necrosis factor alpha, and other cytokines. CRP is
thought to stimulate tissue factor production and activate complement when
aggregated. Tissue factor may be the main stimulus to initiating
coagulation, which could be crucial in CVD development. Also its shown that
CRP binds to low density lipoprotein, which in turn activates complement,
tissue factor production by macrophages leading to coagulation.
Another hypothesis based on findings, that
an infection, possibly a bacterial or a viral (e.g. Helicobacter pylori,
Chlamydia pneumoniae, Herpes simplex virus and cytomegalovirus) might
contribute to atherosclerosis. Having known that CRP levels are increased in
bacterial and viral infections this is quite possible.
A third theory suggests that CRP is a pro
coagulant, increases opsonization and artherogenesis. CRP not only
correlates with the increase in the other inflammatory markers but also is
know to bind selectively to low and very low density lipoprotein (LDL and
VLDL), found in the atheromatous plaque. CRP is also known to be deposited
in these plaques, and along with its range of pro-inflammatory properties it
could potentially contribute to the pathogenesis, progression and
complications of atheroma. Data suggest that CRP is involved in foam cell
formation by mediating the LDL uptake by the macrophages, and also its known
presence in the plaques with pro inflammatory properties, may play a role in
destabilizing the plaque.
During myocardial infraction (MI) the tissue
necrosis occurring is a stimulus for CRP response. The CRP is deposited in
and around infract not only reflects the extent of myocardial necrosis but
also contributes significantly to the severity of ischaemic myocardial
The higher CRP levels are been strongly
associated with increased body mass index and metabolic syndrome. Adipocytes
are the source of substantial portion of baseline IL6 production. Weight
loss leads to reduction in baseline CRP concentration. CRP production
predicts the development of type 2 diabetes independently of traditional
risk factors. Low-insulin response diets may decrease plasma CRP by
influencing adipocyte function. The
elevated CRP levels may provide an additional marker for risk of progression
to type 1 diabetes. Oral
contraceptive use and systemic hormone replacement therapy are associated
with significantly raised baseline CRP levels. Other associations with
elevated baseline CRP values include periodontal disease, smoking,
consumption of coffee, and stress.
With this little knowledge of CRP it would
be certainly interesting to see the relation between CRP and periodontal
disease, and that is what you would read in the third and final part.
~As Understood by me~
References for Part I and II:
Saran de Ferranti, Nadir Rifai,
C-reactive protein and cardiovascular disease: a review of risk prediction
and interventions. Clinical Chimica Acta 2000; 317: 1-15
G.M. Hirschfield and M.B.
Pepys, C-reactive protein and cardiovascular disease: new insights from an
old molecule. Q J Med 2003; 96: 793 Ė 807.
10 Ways to Take Control
by- Cathy Warschaw
Iím really big on positive thinking. Letís face it
negative thinking only makes a person more frustrated, overwhelmed and
simply makes it harder to manage every day responsibilities.
Practicing positive thinking allows people to focus on
their strengths and accomplishments, which increases happiness and
motivation. This, in turn, allows us to spend more time making progress, and
less time feeling down and stuck. The following tips provide practical
suggestions that you can use to help you shift into more positive thinking
1. Take Good Care of Yourself
It's much easier to be positive when you are eating
well, exercising, and getting enough rest.
2. Remind Yourself of the Things You Are Grateful
Stresses and challenges don't seem quite as bad when
you are constantly reminding yourself of the things that are right in life.
Taking just 60 seconds a day to stop and appreciate the good things will
make a huge difference.
3. Look for the Proof Instead of
A fear of not being liked or accepted sometimes leads
us to assume that we know what others are thinking, but our fears are
usually not reality. If you have a fear that a friend or family member's bad
mood is due to something you did, or that your co-workers are secretly
gossiping about you when you turn your back, speak up and ask them. Don't
waste time worrying that you did something wrong unless you have proof that
there is something to worry about.
4. Refrain from Using Absolutes
Have you ever said "You're ALWAYS late!" or complained
to a friend "You NEVER call me!"? Thinking and speaking in absolutes like
'always' and 'never' makes the situation seem worse than it is, and programs
your brain into believing that certain people are incapable of delivering.
5. Detach From Negative Thoughts
Your thoughts can't hold any power over you if you
don't judge them. If you notice yourself having a negative thought, detach
from it, witness it, and don't follow it.
6. Squash the "ANTs"
In his book "Change Your Brain, Change Your Life," Dr.
Daniel Amen talks about "ANTs" - Automatic Negative Thoughts. These are the
bad thoughts that are usually reactionary, like "Those people are laughing,
they must be talking about me," or "The boss wants to see me? It must be
bad!" When you notice these thoughts, realize that they are nothing more
than ANTs and squash them!
7. Practice Lovin', Touchin' & Squeezin' (Your
Friends and Family)
You don't have to be an expert to know the benefits of
a good hug. Positive physical contact with friends, loved ones, and even
pets, is an instant pick-me-up. One research study on this subject had a
waitress touch some of her customers on the arm as she handed them their
checks. She received higher tips from these customers than from the ones she
8. Increase Your Social Activity
By increasing social activity, you decrease loneliness.
Surround yourself with healthy, happy people, and their positive energy will
affect you in a positive way!
9. Volunteer for an Organization, or Help another
Everyone feels good after helping. You can volunteer
your time, your money, or your resources. The more positive energy you put
out into the world, the more you will receive in return.
10. Use Pattern Interrupts to Combat Rumination
If you find yourself ruminating, a great way to stop it
is to interrupt the pattern and force yourself to do something completely
different. Rumination is like hyper-focus on something negative. It's never
productive, because it's not rational or solution-oriented, it's just
excessive worry. Try changing your physical environment - go for a walk or
sit outside. You could also call a friend, pick up a book, or turn on some
When it comes to the work
environment a code of behavior is pretty much the rule of thumb. There are
those who seem to work well under pressure, but every one is different. To
let little things get under our skin won't solve the problem. Sometimes it
takes a bit of courage to admit that we're turning into workaholics rather
than admit to ourselves that we're not doing our best.
© Warschaw Learning Institute 2006
Cathy Warschaw is the Director of the Warschaw Learning
Institute an online educational site offering; Dental Office Management
Program, Telephone Training, HIPAA and various e-books. For more
information go to
www.WarschawLearningInstitute.com or call (323) 822-0917(323) 822-0917.